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No.BCP000725 
Product Name:6-Thioguanine 
Synonyms:2-Amino-6-purinethiol; 2-Amino-6-mercaptopurine; 2-Aminopurine-6(1H)-thione 
Cas No.:154-42-7 
Molecular Formula:C5H5N5S 
Molecular Weight:167.19 
Purity:98% 

 

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Anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model.

LePage (1963) Biochemical effects of 6-Thioguanine. Cancer Res. 23 1202. Wang and Wang (2009) 6-Thioguanine perturbs cytosine methylation at CgP dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry 48 2290. Issaeva et al (2010) 6-Thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Res. 70 6268.

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LY2608204
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BMS-903710
CP154526/CP-154526
TG100801/TG-100801
GSK561679A/GSK-561679A
帕拉米韦
阿莫伦特
KM07978
Metanicotine/TC-2403-12/TC-2403/RJR-2403
SB222200
Org27759
KPT-185
(+/-)-双氮奋兴
6-氨基-7,9-二氢-2-(2-甲氧基乙氧基)-9-(苯甲基)-8H-嘌呤-8-酮
Diisopropylammonium dichloroacetate
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kb-NB142-70
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RU-SKI43
VX-661
β-Alanine, N-[[3-[[(2E)-2-[[(3,5-diamino-6-chloro-2-pyrazinyl)carbonyl]imino]-1,3,8-triazaspiro[4.5]dec-8-yl]carbonyl]phenyl]sulfonyl]-, 2-(dipropylamino)-2-oxoethyl ester, butanedioate (1:?)
2-Pyridinecarboxamide, N-[3-[(3R)-5-amino-3-(difluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methyl-
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with 2-amino-2-methyl-N-[(1R)-2-[(4S,5R)-2-methyl-1-oxo-4-phenyl-2,7-diazaspiro[4.5]dec-7-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]propanamide (1:?)
CETP inhibitor
Z-VAD-FMK
1356331-63-9
2-Pyridinecarboxamide, 3-amino-6-methoxy-N-[(2S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]-5-(trifluoromethyl)-
1H-Indole-4-carboxamide, N,N’-[1,2-ethanediylbis(oxy-3,1-propanediyl)]bis[1-[5-[(2S)-1-(N-methyl-L-alanyl-L-valyl)-2-pyrrolidinyl]-3-pyridinyl]-
Pyrido[4,3-d]pyrimidine, 5,6,7,8-tetrahydro-6-(6-methoxy-5-methyl-3-pyridinyl)-4-[(3S)-3-pyrrolidinyloxy]-
NITD609
7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-[(1R,6S)-9-methyl-4-oxo-3,9-diazabicyclo[4.2.1]non-3-yl]-2-pyridinyl]amino]-
GSK-0660
AMD070
N-[(3R)-3-([1,1’-联苯]-4-氧基)-3-(4-氟苯基)丙基]-N-甲基甘氨酸
NBI-42902
(+)-JQ-1
R428
X-082
CJ-023423
10-脱乙酰基巴卡丁Ⅲ
BAY 11-7085
GSK2578999A
TPEN
GW4869
SG-2202
7-MAC
CHR-6494
GO-6976
GW844520
SGC0946
CY7
exherin
Cy5
TAK-785
LY2623091
LDN-192960
S0859
胸腺素 beta 4
拉氧头孢钠
苔藓抑素
GSK2606414
GSK-2565363
GSK-2578999
GSK-2611483A
GSK-2668871A
GSK-2835574B
GSK-2838232
GSK-2975112A
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GSK-2975176A
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AM555S
TTP22
YS-49
Scriptaid
MK-886
Dapivirine
D-6413
KU14R
YM-90K hydrochloride
LDN-211904
BMS345541
BMS345541
林可霉素
delafloxacine
PF 8380
AM679
RCS-4
Vanoxerine
HC-030031
LVT derivative of Gemcitabine,Gemcitabine elaidate
INNO-206 HCl salt
IDH-C35
gamma-ketotriazole
GSK525762A
7-氨基头孢三嗪
CPI413
Carebastine
AMG-517
新利司他
Debacarb
盐酸去甲乌头碱
吡罗达韦
爱维莫潘
EPZ6438;E7438
UNC1215
2-(吡咯烷-1-基)苯基-1-戊酮
阿伐他汀钠
孕二烯二酮
EPZ-5676
LM-1532
GW-19292
pvp-2
GSK2578999
1422355-65-4
13626-46-5
NKP-608
GPI-1046
GSK 650394
Conduritol B Epoxide
Emricasan
RO 61-8048
Y-352,阿戈美拉汀杂质
PV-8
PFI-1
TMC435350
Bevirimat
辛伐他汀杂质
LDN-57444
SC-144
奈必洛尔
金雀异黄酮
艾沙康唑
D-氢化奎宁-1,4-酞嗪二醚;CB0672988
G-418 硫酸盐
西司他丁
AB-PINACA
Ki-16198
子囊霉素
艾捉非尼
Deferitrin
TAK 599
依普利酮
GSK2578215A
FV-100
MCC257
PA-824
埃博霉素C
Afoxolaner
SteMRegenin 1
瑞替加滨二盐酸盐
坎格雷洛
CPI-203
P005091;P5091
EMD-1214063
LY-2835219
SC-514
GSK-343
VUF11207
TBA-354
Cerpegin
地索苷
LCQ-908
Acotiamide
去氧肾上腺素
3-Deazaneplanocin A hydrochloride
SDZWAG994
LCL-161
Delamanid
P22077
IRAK 抑制剂 6
坎苯达唑
GK2578215A
EPI-743
NHWD-276
卡普瑞林
芬司匹利
MF-63
fub-pb22
MK6096
EPZ005687
ADRIAMYCINOL;RP-27706;RP27706
PluriSln 1
PR-619
PF-03394197
QNZ
乙莫克舍
Osteocalcin fragment 1-49 Human
安丝菌素 P 3
PST2744;PST-2744
PF 02367982
Way255348
BAY58-2667;BAY582667
Alvelestat
VE-822
PACMA-31
PF 4708671
TUG-770
特考韦瑞
艾托立宾
VX11e
PCI-27483
瑞波西汀甲磺酸盐
1-甲基-D-色氨酸
PD123319
Z-Gly-Leu-Phe-chloromethyl ketone
NSC 405020
大麻二酚
GANT61
5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
巴马司他
SGI-7079
CPP-Lysine
4Μ8C
EUK-134
1-脱氧野尻霉素
曲格列汀琥珀酸盐
NSC687852
SCH54292
安丝菌素P-3
TP808
(-)-JQ-1
Fatostatin A
Cytochalasin D
SRPIN340
GSK-J2
TAK-475
GSK-J5
GSK-J1
GSK J4
UNC0642
bromosporine
Poziotinib
JIB-04
SGC-CBP30
I-CBP112
人牛吡啶APELIN-13
5FAB-PINACA
CPI-0610
BI-97C1
LG100268
RI-1
Rigosertib sodium
GF 109203X
Gas6
alisporivir
TCS 1102
C646
雷贝拉唑钠
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