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No.BCP001051 
Product Name:Acetaminophen 
Synonyms:4-Acetamidophenol;p-Hydroxyacetanilide;Paracetamol; N-Acetyl-4-aminophenol; APAP 
Cas No.:103-90-2 
Molecular Formula:C8H9NO2 
Molecular Weight:151.16 
Purity:98% 

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Acetaminophen is a highly selective inhibitor of COX-2 and 6-keto-PGF1 alpha with IC50 of 302.3 mg/kg and 10 µM, respectively. [1] Administration of high-dose AAP [302.3 mg/kg (IC50 for COX-2)] or PHE [179.2 mg/kg (IC50 for COX-2)] and of non-specific (indomethacin: 20 mg/kg) or specific COX-2 (NS-398: 10 mg/kg) inhibitor impaired the performance in hidden platform (HP) not visible platform (VP) tasks, whereas low-dose (15.1 mg/kg) AAP facilitated performance in HP and VP tasks. [2] Nanomolar concentrations of peroxynitrite increased the activity of isolated PGHS and prostacyclin formation by aortic endothelial cells. This elevated activity was efficiently inhibited by pharmacologically relevant concentrations of acetaminophen (IC50 approximately 10 µM for 6-keto-PGF1alpha) and other free radical scavengers. [3]

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